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c/tirzepatide·submitted 2 years ago by u/alcohol_aversion

small win: dual agonist stopped being a problem at week 66

Discussionbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 14 months without either producing anything. What would actually settle it is 23 people measuring the…

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5 comments, started 2 years ago
u/quiet_moderatormod135 points·2 years ago

This matches the trial data. SURMOUNT-1 was 93.7% body weight at 4 weeks.

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u/samir_falk68 points·2 years ago·edited

the dual agonism hits different and that is why people describe it differently

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u/laila_wikstrom35 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/hassan_nilsen9 points·2 years ago

Slight fix: the number was 98.0, not 98.1. Decimal point, but a fairly consequential one.

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u/ferritin_low-35 points·2 years ago

This matches the trial data.

Yes, exactly this, and it is the bit that took me 13 weeks to accept.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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