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c/tirzepatide·submitted 2 years ago by u/throwaway_titration

the SURPASS thing finally clicked for me and I want to write it down

Labbranch of 7 comments

Confession thread, sort of. I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have constipation…

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7 comments, started 2 years ago
u/priya_guerrero31 points·2 years ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/zeynep_ndiaye21 points·2 years ago

Is that on Mounjaro pens or research tirzepatide?

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u/throwaway_titrationOP15 points·2 years ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/zaid_balogun12 points·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/zeynep_zielinski12 points·2 years ago

Vial-splitting is on-topic here.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/emil_okwuosa10 points·2 years ago·edited

week 47 on Mounjaro and the appetite profile is genuinely different from sema

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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