the SURPASS thing finally clicked for me and I want to write it down
Confession thread, sort of.
I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 71 reads it before doing the same thing.
best — the order this archive was captured in
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
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Zepbound and Mounjaro are literally the same drug, the name is the only difference
do not crack the pen, we have been over this
the GIP side does different things than the GLP-1 side, that is the point
Did the reflux feel the same as on tirz or genuinely different?
How long at each step before you escalated?
Retitled to remove editorialising. Put the evidence in the body.
SURMOUNT data is messier than STEP data but the weight loss is there
Disagree. What you are describing is consistent with tirzepatide, not with what you concluded.
stalled on sema, tried tirz, and the curves were actually different shapes
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
the 15mg is the top of the pen, not the required dose
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
the GIP side does different things than the GLP-1 side, that is the point
the GIP side does different things than the GLP-1 side, that is the point
Disagree on that part. 98.7% and 98.9% on the same vial is normal.
the dual agonism hits different and that is why people describe it differently
the appetite change on tirz is more than just reduced hunger, it is different machinery
This is the "correlation is mechanism" thing again. You changed three variables at once.
do not crack the pen, we have been over this
My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.
This matches the trial data. SURMOUNT-1 was 99.0% body weight at 22 weeks.
Hard agree. The food noise disappears differently on the two compounds.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Is that on Mounjaro pens or research tirzepatide?
Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.
the dual agonism hits different and that is why people describe it differently
Vial-splitting is on-topic here.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
week 47 on Mounjaro and the appetite profile is genuinely different from sema
dual agonism is SURPASS, do not generalise from semaglutide
- 1the GIP side does different things than the GLP-1 side, that is the point7 comments in this branch · started by u/mod_cold_room
- 2the appetite change on tirz is more than just reduced hunger, it is…7 comments in this branch · started by u/priya_guerrero