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c/tirzepatide·submitted 2 years ago by u/throwaway_titration

the SURPASS thing finally clicked for me and I want to write it down

Labbranch of 7 comments

Confession thread, sort of. I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have constipation…

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7 comments, started 2 years ago
u/mod_cold_roommod · c/coldchain55 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

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u/dario_vermeulen37 points·2 years ago

the GIP side does different things than the GLP-1 side, that is the point

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/gentle_correctionnice about it15 points·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/hugo_bergstrom10 points·2 years ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/incretin_ivypharmacology16 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/two_mil_or_one4 points·2 years ago

do not crack the pen, we have been over this

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u/throwaway_titrationOP2 points·2 years ago

My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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