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c/tirzepatide·submitted 7 days ago by u/emil_okwuosa

why is nobody talking about the SURPASS-CVOT readout

Labbranch of 5 comments

Right, the SURPASS question again, but with numbers this time. I have 22 data points over 36 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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5 comments, started 5 days ago
u/customs_seizure_sid115 points·5 days ago·edited

Did the fatigue feel the same as on tirz or genuinely different?

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u/elin_ferrari33 points·5 days ago

dual agonism is 15mg, do not generalise from semaglutide

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u/emil_okwuosaOP-12 points·5 days ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/kian_ekstrom-16 points·5 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/ahmed_fonseca14 points·5 days ago

Respectfully this is a sample of one presented as a finding.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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