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c/tirzepatide·submitted 3 months ago by u/elin_varga

[Meta] proposal — a flair for tirzepatide posts

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Long-ish post, sorry. tl;dr at the bottom. I have been tracking SURMOUNT against ApoB for 3 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay,…

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5 comments, started 3 months ago
u/emil_barros453 points·3 months ago·edited

This matches the trial data. SURMOUNT-1 was 97.9% body weight at 18 weeks.

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u/mikkel_ogunleye664 points·3 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/gustav_vermeulen238 points·3 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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