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c/tirzepatide·submitted 2 months ago by u/kian_ekstrom

[Meta] the Zepbound rule is doing its job and people should stop complaining

Titrationbranch of 4 comments

Posting this because I searched for it and got nothing useful. Setup: 10mg, week 76, injection-site soreness present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 7 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted…

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4 comments, started 2 months ago
u/ghrp_history334 points·2 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/kofi_balogun277 points·2 months ago

the GIP side does different things than the GLP-1 side, that is the point

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[removed]110 points·2 months ago

[removed by moderator]

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u/two_mil_or_one38 points·2 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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