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c/tirzepatide·submitted 3 months ago by u/alcohol_aversion

reading SURMOUNT threads from 2024 and half of it aged badly

Side Effectsbranch of 7 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 7 people measuring the…

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7 comments, started 3 months ago
u/quiet_moderatorMOD23 points·3 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/alcohol_aversionOP-30 points·3 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/alcohol_aversionOP1 point·3 months ago

do not crack the pen, we have been over this

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u/gustav_vermeulen1 point·3 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/nabila_ogunleye11 points·3 months ago

Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.

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u/cormac_pereira9 points·3 months ago·edited

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/noor_hovland4 points·3 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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