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c/tirzepatide·posted 3 months ago by u/alcohol_aversion

reading SURMOUNT threads from 2024 and half of it aged badly

Side Effects Clean Column ×4

Trying to settle this properly because the thread from last year went in circles.

The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything.

What would actually settle it is 7 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

3,730 up / 3,271 down53% upvoted21 commentsid 1sd0zx26 Apr 2026

21 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/amara_halonen0 points·3 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/alcohol_aversionOP1 point·3 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/spain_receta1 point·3 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/neha_falk1 point·3 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/ferran_mensah33 points·3 months ago

Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.

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u/tarek_kirchner12 points·3 months ago

week 13 on Mounjaro and the appetite profile is genuinely different from sema

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u/georgi_chowdhury11 points·3 months ago

Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.

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u/customs_seizure_sid9 points·3 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/quiet_moderatorMOD23 points·3 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/alcohol_aversionOP-30 points·3 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/alcohol_aversionOP1 point·3 months ago

do not crack the pen, we have been over this

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u/gustav_vermeulen1 point·3 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/nabila_ogunleye11 points·3 months ago

Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.

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u/cormac_pereira9 points·3 months ago·edited

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/noor_hovland4 points·3 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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