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c/tirzepatide·submitted 3 months ago by u/alcohol_aversion

reading SURMOUNT threads from 2024 and half of it aged badly

Side Effectsbranch of 4 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 7 people measuring the…

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4 comments, started 3 months ago
u/amara_halonen0 points·3 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/alcohol_aversionOP1 point·3 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/spain_receta1 point·3 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/neha_falk1 point·3 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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