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c/tirzepatide·submitted 8 months ago by u/ferritin_low

anyone else notice 15mg kicking in around week 24

Labbranch of 16 comments

Posting this because I searched for it and got nothing useful. Setup: 1.0mg, week 62, injection-site soreness present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 19 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted…

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16 comments, started 8 months ago
u/quiet_moderatorMOD143 points·8 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/hugo_bergstrom41 points·8 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/nordic_pricing28 points·8 months ago

week 95 on Mounjaro and the appetite profile is genuinely different from sema

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u/ingrid_correia39 points·8 months ago

Not convinced. The evidence does not support that reading.

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u/adnan_nascimento13 points·8 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/ferritin_lowOP24 points·8 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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[removed]28 points·8 months ago

[removed by moderator]

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u/neha_falk76 points·8 months ago

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

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u/yusuf_ramos96 points·8 months ago

dual agonism is Mounjaro, do not generalise from semaglutide

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u/alcohol_aversion39 points·8 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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u/ferritin_lowOP43 points·8 months ago

This matches the trial data. SURMOUNT-1 was 99.2% body weight at 20 weeks.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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