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c/tirzepatide·submitted 7 months ago by u/emil_barros

switched from 7.5mg to 15mg and the nausea got better, not worse

Titrationbranch of 8 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 2 months without either producing anything. What would actually settle it is 11 people measuring the same…

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8 comments, started 7 months ago
u/bastian_ekstrom80 points·7 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/quiet_moderatorMOD47 points·7 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/fatima_wojcik33 points·7 months ago

week 17 on Mounjaro and the appetite profile is genuinely different from sema

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u/ahmed_iyer20 points·7 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/emil_barrosOP12 points·7 months ago

Week 57 on Mounjaro and 45kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/samir_falk36 points·7 months ago

the 15mg is the top of the pen, not the required dose

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u/swirl_dont_shakereconstitution15 points·7 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/rania_diallo19 points·7 months ago

the fatigue from tirz is different, not necessarily worse

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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