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c/tirzepatide·posted 4 months ago by u/piotr_nascimento

SURMOUNT — my 11-week log, condensed into one table

Titration

Been lurking in c/orforglipron for about 12 months and finally have something worth posting.

Short version: week 3, 5mg, and dual agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 37 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 9.

329 up / 102 down76% upvoted20 commentsid 1th2k726 Mar 2026

20 comments

18 in this archive, depth 5

best — the order this archive was captured in

u/discount_math_dm24 points·4 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/piotr_nascimentoOP18 points·4 months ago

My eGFR moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/slow_logbook_ftw14 points·4 months ago·edited

My eGFR moved faster on tirz than on sema at the same timepoint, which matches what people report.

Disagree on that part. 98.1% and 97.6% on the same vial is normal.

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u/piotr_nascimento3 points·4 months ago

Small correction: the trial was 4 weeks, not 32. Does not change your point but people will quote it.

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u/gustav_vermeulen8 points·4 months ago·edited

the early fullness from tirz is different, not necessarily worse

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u/rania_marchand-23 points·4 months ago

I love that this community will spend 40 comments on a detail.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/titration_marshalMOD26 points·4 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/aurel_lindqvist7 points·4 months ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/dexa_twice_yearlybody comp7 points·4 months ago

the GIP side does different things than the GLP-1 side, that is the point

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[removed]3 points·4 months ago

[removed by moderator]

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u/titration_marshalmod · c/semaglutide6 points·4 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

Yes, exactly this, and it is the bit that took me 56 weeks to accept.

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u/piotr_nascimentoOP20 points·4 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/hassan_nilsen16 points·4 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/neha_falk4 points·4 months ago

do not crack the pen, we have been over this

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u/hassan_nilsen3 points·4 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/sten_bhattacharya1 point·4 months ago·edited

the 15mg is the top of the pen, not the required dose

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u/copay_card_cc1 point·4 months ago

the 15mg is the top of the pen, not the required dose

Adding to this: Mounjaro is doing more work than the comment implies.

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u/kian_ekstrom10 points·4 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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