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c/tirzepatide·submitted 7 months ago by u/mikkel_ogunleye

[Discussion] we are measuring 15mg at the wrong time and calling it noise

Discussionbranch of 7 comments

Right, the Mounjaro question again, but with numbers this time. I have 17 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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7 comments, started 6 months ago
u/sten_palacios199 points·6 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/titration_marshalmod · c/semaglutide101 points·6 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/elin_ferrari46 points·6 months ago

the fatigue from tirz is different, not necessarily worse

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u/sofia_nascimento31 points·6 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/mikkel_ogunleye8 points·6 months ago

Did the sulphur burps feel the same as on tirz or genuinely different?

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u/mikkel_ogunleyeOP12 points·6 months ago

Small correction: the trial was 17 weeks, not 31. Does not change your point but people will quote it.

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u/ahmed_fonseca123 points·6 months ago

Hard agree. The food noise disappears differently on the two compounds.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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