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c/tirzepatide·submitted 4 months ago by u/nabila_ogunleye

someone explain 15mg to me like I have not read a paper in years

Titrationbranch of 8 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on SURPASS in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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8 comments, started 4 months ago
u/emil_wojcik52 points·4 months ago

the nausea from tirz is different, not necessarily worse

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u/samir_falk15 points·4 months ago

Tried both. Sema worked, tirz worked better for me, but my injection-site soreness profile was worse on tirz.

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u/nabila_ogunleyeOP27 points·4 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/hair_shed_hannah33 points·4 months ago

the GIP side does different things than the GLP-1 side, that is the point

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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