someone explain 15mg to me like I have not read a paper in years
Something I noticed reading old threads that I have not seen said out loud.
The advice on SURPASS in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
SURMOUNT data is messier than STEP data but the weight loss is there
This matches the trial data. SURMOUNT-1 was 94.2% body weight at 3 weeks.
dual agonism is Mounjaro, do not generalise from semaglutide
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This matches the trial data. SURMOUNT-1 was 98.1% body weight at 15 weeks.
Week 63 on Mounjaro and 38kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
the 15mg is the top of the pen, not the required dose
the muscle cramps from tirz is different, not necessarily worse
Disagree. What you are describing is consistent with SURMOUNT, not with what you concluded.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
do not crack the pen, we have been over this
the nausea from tirz is different, not necessarily worse
Tried both. Sema worked, tirz worked better for me, but my injection-site soreness profile was worse on tirz.
This is the "correlation is mechanism" thing again. You changed three variables at once.
the GIP side does different things than the GLP-1 side, that is the point
How long at each step before you escalated?
dual agonism is SURPASS, do not generalise from semaglutide
Zepbound and Mounjaro are literally the same drug, the name is the only difference
Small correction: the trial was 14 weeks, not 39. Does not change your point but people will quote it.
- 1Three years on this site and the questions have not changed at all. Which is…8 comments in this branch · started by u/tidy_vialdrawer_pls
- 2the nausea from tirz is different, not necessarily worse8 comments in this branch · started by u/emil_wojcik