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c/tirzepatide·submitted 4 months ago by u/nabila_ogunleye

someone explain 15mg to me like I have not read a paper in years

Titrationbranch of 8 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on SURPASS in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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8 comments, started 4 months ago
u/tidy_vialdrawer_pls145 points·4 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/quiet_moderatormod119 points·4 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/blunt_coldbox2996 points·4 months ago

This matches the trial data. SURMOUNT-1 was 94.2% body weight at 3 weeks.

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u/emil_wojcik31 points·4 months ago·edited

dual agonism is Mounjaro, do not generalise from semaglutide

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[removed]44 points·4 months ago

[removed by moderator]

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u/sten_bhattacharya33 points·4 months ago

This matches the trial data. SURMOUNT-1 was 98.1% body weight at 15 weeks.

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u/nabila_ogunleyeOP92 points·4 months ago

Week 63 on Mounjaro and 38kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/nabila_ogunleyeOP34 points·4 months ago

the 15mg is the top of the pen, not the required dose

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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