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c/tirzepatide·submitted 1 year ago by u/blunt_coldbox29

anyone else notice tirzepatide kicking in around week 20

Resultsbranch of 11 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything. What would actually settle it is 11 people measuring the same…

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11 comments, started 1 year ago
u/quiet_moderatorMOD387 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[deleted]253 points·1 year ago

[deleted]

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u/georgi_chowdhury80 points·1 year ago

dual agonism is GIP, do not generalise from semaglutide

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u/tarek_kirchner185 points·1 year ago·edited

Hard agree. The food noise disappears differently on the two compounds.

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u/ewan_marchand65 points·1 year ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/gustav_vermeulen59 points·1 year ago

I am going to push back on this slightly.

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u/incretin_ivypharmacology108 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/piotr_nascimento26 points·1 year ago

do not crack the pen, we have been over this

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u/zaid_balogun66 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/throwaway_wl202623 points·1 year ago

the dual agonism hits different and that is why people describe it differently

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u/blunt_coldbox29OP26 points·1 year ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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