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c/tirzepatide·submitted 1 year ago by u/nz_unfunded

[Meta] the SURMOUNT rule is doing its job and people should stop complaining

Discussionbranch of 9 comments

Been lurking in c/compounding for about 13 months and finally have something worth posting. Short version: week 29, 0.5mg, and GIP is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 13 threads, and the answers split roughly down the middle. What I actually want to know is…

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9 comments, started 1 year ago
u/georgi_chowdhury153 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/bastian_ekstrom117 points·1 year ago

Cosigning.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/aurel_lindqvist28 points·1 year ago

week 70 on Mounjaro and the appetite profile is genuinely different from sema

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u/cato_girard102 points·1 year ago·edited

How long at each step before you escalated?

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u/spain_receta75 points·1 year ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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u/incretin_ivypharmacology-18 points·1 year ago

This matches the trial data. SURMOUNT-1 was 97.4% body weight at 23 weeks.

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u/dario_stanescu0 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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