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c/tirzepatide·submitted 1 months ago by u/copay_card_cc

small win: GIP stopped being a problem at week 31

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Week 45 update. 46kg down from the start, early fullness basically gone since about week 85. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness. The part that surprised me is how much of this is…

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8 comments, started 1 months ago
u/quiet_moderatorMOD138 points·1 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/throwaway_wl2026112 points·1 months ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/hana_pereira51 points·1 months ago·edited

do not crack the pen, we have been over this

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u/laila_yilmaz0 points·1 months ago

Is that on Mounjaro pens or research tirzepatide?

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u/emil_wojcik1 point·1 months ago

week 79 on Mounjaro and the appetite profile is genuinely different from sema

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u/endpoint_creep39 points·1 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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