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c/tirzepatide·submitted 1 months ago by u/aksel_kjaer

[Meta] the 15mg rule is doing its job and people should stop complaining

Resultsbranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 12.5mg, week 16, constipation present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 11 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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8 comments, started 1 months ago
u/incretin_ivypharmacology132 points·1 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/yusuf_ramos63 points·1 months ago·edited

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/laila_yilmaz21 points·1 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/curious_panel_only50 points·1 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/aksel_kjaerOP29 points·1 months ago

the dual agonism hits different and that is why people describe it differently

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u/b12_baseline11 points·1 months ago·edited

the appetite change on tirz is more than just reduced hunger, it is different machinery

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[removed]4 points·1 months ago

[removed by moderator]

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u/nz_unfunded1 point·1 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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