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c/tirzepatide·submitted 1 months ago by u/aksel_kjaer

[Meta] the 15mg rule is doing its job and people should stop complaining

Resultsbranch of 6 comments

Posting this because I searched for it and got nothing useful. Setup: 12.5mg, week 16, constipation present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 11 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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6 comments, started 1 months ago
u/endpoint_creep38 points·1 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/aksel_kjaerOP15 points·1 months ago

dual agonism is Mounjaro, do not generalise from semaglutide

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u/sanne_novak11 points·1 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/search_before_post-19 points·1 months ago

Strongly agree.

Disagree on that part. 99.0% and 98.9% on the same vial is normal.

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u/ewan_marchand0 points·1 months ago

do not crack the pen, we have been over this

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u/fatima_wojcik1 point·1 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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