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c/tirzepatide·submitted 19 days ago by u/discount_math_dm

anyone else find 15mg genuinely unpleasant with no extra loss

Titrationbranch of 6 comments

Right, the SURPASS question again, but with numbers this time. I have 12 data points over 12 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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6 comments, started 19 days ago
u/aksel_kjaer13 points·19 days ago

Tried both. Sema worked, tirz worked better for me, but my constipation profile was worse on tirz.

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u/titration_marshalMOD7 points·19 days ago

Retitled to remove editorialising. Put the evidence in the body.

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u/discount_math_dmOP4 points·18 days ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/priya_guerrero3 points·18 days ago

the dual agonism hits different and that is why people describe it differently

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u/throwaway_titration1 point·18 days ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/discount_math_dmOP4 points·18 days ago

the 15mg is the top of the pen, not the required dose

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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