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c/tirzepatide·submitted 1 year ago by u/gentle_correction

tried tirzepatide for 24 weeks. here is what happened.

Side Effectsbranch of 7 comments

Posting this because I searched for it and got nothing useful. Setup: 2.4mg, week 14, injection-site soreness present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 16 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted…

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7 comments, started 1 year ago
u/hub_opssite staff403 points·1 year ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/zeynep_ndiaye173 points·1 year ago

the GIP side does different things than the GLP-1 side, that is the point

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u/b12_baseline132 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/marit_sandvik29 points·1 year ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/dexa_twice_yearlybody comp8 points·1 year ago

Small correction: the trial was 10 weeks, not 10. Does not change your point but people will quote it.

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u/britt_okwuosa294 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/kian_ekstrom122 points·1 year ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Disagree on that part. 99.2% and 99.3% on the same vial is normal.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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