reading 15mg threads from 2024 and half of it aged badly
Genuinely asking, not being difficult.
Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 13 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
the dual agonism hits different and that is why people describe it differently
the dual agonism hits different and that is why people describe it differently
Adding to this: Mounjaro is doing more work than the comment implies.
My hs-CRP moved faster on tirz than on sema at the same timepoint, which matches what people report.
the dual agonism hits different and that is why people describe it differently Adding to this: Mounjaro is doing more work than the comment implies.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
Removed a chain here. The rule is one line long and it is not negotiable.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
How long at each step before you escalated?
the nausea from tirz is different, not necessarily worse
the early fullness from tirz is different, not necessarily worse
the dual agonism hits different and that is why people describe it differently
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
the 15mg is the top of the pen, not the required dose
Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
week 13 on Mounjaro and the appetite profile is genuinely different from sema
the fatigue from tirz is different, not necessarily worse
This matches the trial data. SURMOUNT-1 was 98.3% body weight at 21 weeks.
the muscle cramps from tirz is different, not necessarily worse
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This matches the trial data. SURMOUNT-1 was 94.2% body weight at 9 weeks.
the 15mg is the top of the pen, not the required dose
This matches the trial data.
Adding to this: dual agonist is doing more work than the comment implies.
the dual agonism hits different and that is why people describe it differently
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Yes, exactly this, and it is the bit that took me 16 weeks to accept.
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
stalled on sema, tried tirz, and the curves were actually different shapes
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
the the food-noise thing from tirz is different, not necessarily worse
- 1the 15mg is the top of the pen, not the required dose13 comments in this branch · started by u/swirl_dont_shake
- 2The dual agonism story is real. The appetite is physically different from…8 comments in this branch · started by u/santiago_villalobos