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c/tirzepatide·posted 1 year ago by u/kaia_wojcik

what changed for me between week 35 and week 78

Side Effects Clean Column ×2 Long Haul ×1 Well Actually ×1

Quick one. Canada here.

Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.

Specifics: the route I used took 16 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.

Happy to answer questions from anyone in the same jurisdiction.

5,031 up / 830 down86% upvoted26 commentsid sl1e233 Jan 2025

26 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/amara_halonen599 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/noor_hovland561 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/kaia_wojcikOP404 points·1 year ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/ahmed_fonseca0 points·1 year ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/swirl_dont_shakereconstitution305 points·1 year ago

the muscle cramps from tirz is different, not necessarily worse

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[deleted]207 points·1 year ago

[deleted]

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u/tove_vasquez71 points·1 year ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/tove_vasquez259 points·1 year ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/sanne_novak359 points·1 year ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

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u/sten_palacios152 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/kaia_wojcik-26 points·1 year ago

do not crack the pen, we have been over this

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u/kaia_wojcikOP1 point·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/signe_villalobos209 points·1 year ago·edited

Titration speed is a side-effect dial far more than an efficacy dial.

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u/incretin_ivyMOD85 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/emil_barros192 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/thyroid_tangent116 points·1 year ago

I am going to push back on this slightly.

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u/kaia_wojcikOP47 points·1 year ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/mikkel_ogunleye79 points·1 year ago·edited
source?
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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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