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c/tirzepatide·posted 1 year ago by u/halima_boateng

three years of SURPASS threads, summarised so you do not have to read them

Trial Data Well Actually ×9 The Quiet One ×1

Genuinely asking, not being difficult.

Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

3,197 up / 745 down81% upvoted20 commentsid sv0zr214 Jan 2025

20 comments

5 in this archive, depth 2

best — the order this archive was captured in

u/dexa_twice_yearlybody comp254 points·1 year ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/noor_hovland302 points·1 year ago

the reflux from tirz is different, not necessarily worse

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u/mod_cold_roommod · c/coldchain236 points·1 year ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/titration_marshalMOD130 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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[removed]91 points·1 year ago

[removed by moderator]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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