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c/trialwatch·submitted 1 year ago by u/marit_laurent

reading endpoint threads from 2024 and half of it aged badly

Discussionbranch of 4 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 23 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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4 comments, started 1 year ago
u/hazard_ratio_halstats137 points·1 year ago

Mechanistically the bit that matters is SELECT. It explains most of the early profile and a decent chunk of the outcome.

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u/rania_salinas87 points·1 year ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/valeria_karlsen57 points·1 year ago

dropout handling matters, especially on GI-heavy populations

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