[Discussion] the SURPASS advice in here is 8 years out of date
Right, the TRIUMPH question again, but with numbers this time.
I have 14 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 63, not week 17. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
the relative risk reduction in headlines is not the whole story
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give the trial name, phase, n, and primary endpoint in the body
This is correct. Discontinuation arms show the regain reality.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
Yeah, absolute numbers matter more than the press release.
the 9 week readout is different from the 21 week readout
Half-life is about 168 hours, so steady state lands around week 14–5. Practical consequence: what you feel in week 1 is not what that dose does.
Is that absolute or relative risk reduction?
number-needed-to-treat is the house dialect
phase 2 is not phase 3, smaller n and shorter trial
give the trial name, phase, n, and primary endpoint in the body
The confident tone is doing a lot of work that the evidence is not.
off-label use data is different from approved-indication data
- 1This is correct. Discontinuation arms show the regain reality.4 comments in this branch · started by u/nightowl_injector