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c/trialwatch·submitted 2 months ago by u/joaquin_trevino

SELECT: the version I wish someone had shown me in week 1

Trial Databranch of 9 comments

Quick one. Canada here. SURPASS works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 13 weeks and cost roughly what I expected. The admin was worse than the…

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9 comments, started 2 months ago
u/gastric_emptying_g58 points·2 months ago

Is that absolute or relative risk reduction?

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u/alcohol_aversion69 points·2 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/joaquin_trevino86 points·2 months ago

the 24 week readout is different from the 28 week readout

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u/britta_boateng35 points·2 months ago

This is correct. Discontinuation arms show the regain reality.

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u/ms_fragmenter40 points·2 months ago

the discontinuation arms are the interesting part, not the SURPASS endpoints

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u/hazard_ratio_halstats29 points·2 months ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/milos_trevino22 points·2 months ago

the discontinuation arms are the interesting part, not the FLOW endpoints

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u/hamza_zielinski27 points·2 months ago

off-label use data is different from approved-indication data

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u/emil_agyeman35 points·2 months ago

STEP 1 readout: 98.3% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

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