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c/trialwatch·posted 2 years ago by u/rohan_steiner

am I the only one who found SURMOUNT harder than the injections

Trial Data Well Actually ×8 Long Haul ×3

Right, the SURMOUNT question again, but with numbers this time.

I have 13 data points over 18 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 34, not week 83. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

2,627 up / 61 down98% upvoted46 commentsid 15azwo14 Nov 2023

46 comments

9 in this archive, depth 5

best — the order this archive was captured in

u/rohan_cardoso0 points·2 years ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/forest_plot_fionaMOD1 point·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/hsa_math-19 points·2 years ago

event rates are more informative than hazard ratios alone

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u/paper_trail_paulavetting1 point·2 years ago

the 15 week readout is different from the 14 week readout

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u/rulebook_rachaelmod · c/meta1 point·2 years ago·edited

This is correct. Discontinuation arms show the regain reality.

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u/camila_vasquez1 point·2 years ago

Phase 2 or phase 3?

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u/rina_sobczak1 point·2 years ago

give the trial name, phase, n, and primary endpoint in the body

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[deleted]1 point·2 years ago

[deleted]

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u/customs_seizure_sid1 point·2 years ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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