genuine question about SELECT that I am slightly embarrassed to ask
Week 45 update. 16kg down from the start, reflux basically gone since about week 85.
Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.
The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.
Happy to answer anything. Please do not ask me what dose you should be on.
best — the order this archive was captured in
the discontinuation arms are the interesting part, not the SURPASS endpoints
the relative risk reduction in headlines is not the whole story
Strongly agree. Phase 2 is investigational, not conclusive.
Removed a chain here. The rule is one line long and it is not negotiable.
I am going to push back on this slightly.
The confident tone is doing a lot of work that the evidence is not.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
dropout handling matters, especially on GI-heavy populations
event rates are more informative than hazard ratios alone
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
the discontinuation arms are the interesting part, not the STEP endpoints
off-label use data is different from approved-indication data
off-label use data is different from approved-indication data
Yes, exactly this, and it is the bit that took me 95 weeks to accept.
This is the "correlation is mechanism" thing again. You changed three variables at once.
the 22 week readout is different from the 24 week readout
STEP 1 readout: 99.2% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
- 1Rodent data is rodent data. Dose scaling is not linear and the models tell…4 comments in this branch · started by u/yara_bakken