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c/trialwatch·submitted 6 months ago by u/nordic_pricing

the hazard ratio thing finally clicked for me and I want to write it down

Discussionbranch of 9 comments

STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does. I say this having got it wrong for 8 months. My eGFR was…

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9 comments, started 6 months ago
u/cesar_ivaturi360 points·6 months ago

This is correct. Discontinuation arms show the regain reality.

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u/hazard_ratio_halMOD213 points·6 months ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/tomas_kimani51 points·6 months ago

dropout handling matters, especially on GI-heavy populations

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[deleted]37 points·6 months ago

[deleted]

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u/emil_agyeman18 points·6 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/iman_castellanos-6 points·6 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/nhs_waitlist_nUK1 point·6 months ago

the discontinuation arms are the interesting part, not the FLOW endpoints

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u/receipts_or_nothingvetting1 point·6 months ago·edited

give the trial name, phase, n, and primary endpoint in the body

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