[Results] 7 weeks, 30kg, and STEP was the hard part
Posting this because I searched for it and got nothing useful.
Setup: 0.5mg, week 55, sulphur burps present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 4 weeks.
Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.
Not medical advice, obviously. This is one person with a spreadsheet.
best — the order this archive was captured in
This is correct. Discontinuation arms show the regain reality.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
dropout handling matters, especially on GI-heavy populations
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
Strongly agree. Phase 2 is investigational, not conclusive.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
STEP 1 readout: 94.2% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
the discontinuation arms are the interesting part, not the FLOW endpoints
off-label use data is different from approved-indication data
Strongly agree. Phase 2 is investigational, not conclusive.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
This is correct. Discontinuation arms show the regain reality.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
Yeah, absolute numbers matter more than the press release.
- 1Dead space in the needle hub holds a small but non-trivial volume. On…7 comments in this branch · started by u/ines_castellanos
- 2This is correct. Discontinuation arms show the regain reality.6 comments in this branch · started by u/plateau_patrol