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c/trialwatch·submitted 12 months ago by u/hedda_adeyemi

help me understand endpoint, I have read the wiki twice

Readoutbranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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7 comments, started 12 months ago
u/yusuf_achebe56 points·12 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/ahmed_iyer31 points·12 months ago

Which trial and what was the primary endpoint?

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u/piotr_bruun13 points·12 months ago

the 12 week readout is different from the 18 week readout

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u/gastric_emptying_g19 points·12 months ago

phase 2 is not phase 3, smaller n and shorter trial

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u/draw_up_dizzy13 points·12 months ago

phase 2 is not phase 3, smaller n and shorter trial

Disagree on that part. 95.1% and 98.9% on the same vial is normal.

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u/careful_gradient_again10 points·12 months ago

dropout handling matters, especially on GI-heavy populations

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u/draw_up_dizzy4 points·12 months ago

the relative risk reduction in headlines is not the whole story

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