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c/trialwatch·submitted 1 year ago by u/laila_almeida

tried SURPASS for 11 weeks. here is what happened.

Readoutbranch of 5 comments

Genuinely asking, not being difficult. Everyone in c/compounding repeats that hazard ratio is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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5 comments, started 1 year ago
u/rulebook_rachaelmod · c/meta104 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/nora_oyelaran81 points·1 year ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/rohan_steiner-6 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/hub_opssite staff1 point·1 year ago

the discontinuation arms are the interesting part, not the TRIUMPH endpoints

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u/joaquin_stanescu1 point·1 year ago

the discontinuation arms are the interesting part, not the TRIUMPH endpoints

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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