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Single comment threadYou are looking at one branch of FLOW got published and nobody in here is talking about eGFR slope — 30 comments in the full submission. View in context.
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c/trialwatch·submitted 3 days ago by u/ines_castellanos

FLOW got published and nobody in here is talking about eGFR slope

Paperbranch of 12 comments

Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 20 weeks and cost roughly what I expected. The admin was worse than the…

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12 comments, started 2 days ago
u/plateau_patrol27 points·2 days ago
okay but what dose
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u/zaid_roos21 points·2 days ago

Small correction: the trial was 17 weeks, not 13. Does not change your point but people will quote it.

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u/rt_shift_reggie7 points·2 days ago·edited

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/first_hundred6 points·2 days ago

the relative risk reduction in headlines is not the whole story

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u/ines_castellanosOP3 points·2 days ago

SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.

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u/renal_outcomes_rnephro-curious-17 points·2 days ago

phase 2 is not phase 3, smaller n and shorter trial

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u/curious_panel_only5 points·2 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/receipts_or_nothingvetting4 points·2 days ago

Yeah, absolute numbers matter more than the press release.

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u/alcohol_aversion3 points·1 days ago·edited

Small correction: the trial was 8 weeks, not 9. Does not change your point but people will quote it.

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[removed]4 points·2 days ago

[removed by moderator]

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u/arne_ilunga15 points·2 days ago

Small correction: the trial was 17 weeks, not 13.

Adding to this: SELECT is doing more work than the comment implies.

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u/niels_norgaard0 points·2 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

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