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c/trialwatch·posted 1 year ago by u/adaeze_weiss

the FLOW question that gets asked weekly, answered properly

Readout

STEP. That is the whole post, but I will justify it.

Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does.

I say this having got it wrong for 14 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

270 up / 305 down47% upvoted11 commentsid zhtdp815 Oct 2024

11 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/anders_karlsen8 points·1 year ago

Yeah, absolute numbers matter more than the press release.

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u/plateau_patrol2 points·1 year ago

Phase 2 or phase 3?

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u/adaeze_weissOP6 points·1 year ago

Yeah, absolute numbers matter more than the press release.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/rulebook_rachaelmod · c/meta1 point·1 year ago

Yeah, absolute numbers matter more than the press release.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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u/forest_plot_fionaMOD6 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/emil_agyeman7 points·1 year ago

give the trial name, phase, n, and primary endpoint in the body

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u/hugo_bergstrom5 points·1 year ago

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

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u/milos_vanhecke4 points·1 year ago

phase 2 is not phase 3, smaller n and shorter trial

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