u/bilal_osei

Not to be pedantic but weekly dosing and Wegovy are being used interchangeably and they are not interchangeable in real life.

Rodent, human, or in vitro?

Not convinced. The evidence does not support that reading.

the glucagon component changes the side effect profile, not just the efficacy

okay but what dose of sema are you on

do not extrapolate rodent data to human dosing without saying so

Are you quoting phase 2 or is there phase 3 data now?

This is correct. The shortage list does expire and the rules change.

central appetite signalling is real but people overweight it

TRIUMPH phase 2 showed 99.1% weight loss but the injection-site soreness profile on the highest arm was rough.

Yes, exactly this, and it is the bit that took me 89 weeks to accept.

Not convinced.

Yes, exactly this, and it is the bit that took me 83 weeks to accept.

Mechanistically the bit that matters is triple agonist.

Disagree on that part. 98.3% and 98.4% on the same vial is normal.

phase 2 numbers are not maintenance numbers, cite the trial

Yeah, 503A and 503B are different regulatory animals.

titration speed is Ozempic plus side effects, period

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

the constipation passes. i promise. not medical advice.

the 2.4mg dose is not the target, it is just what the pen goes up to

state board rules differ, say which state

heart rate and dose escalation need actual measurements, not impressions

This is the "correlation is mechanism" thing again. You changed three variables at once.