u/elin_lundgren

Half-life is about 168 hours, so steady state lands around week 14–5. Practical consequence: what you feel in week 1 is not what that dose does.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

rodent half-life tells you what to investigate, not what to expect in humans

Not to be pedantic but co-agonism and satiety are being used interchangeably and they are not interchangeable in real life.

tendon and CagriSema literature in rodents is interesting

Yeah, amylin is doing different work than GLP-1.

week 29 and the nausea is finally getting better

Yeah, the constipation hit on day 10 for me too, not day 1.

This is correct. The early fullness is horrible for three weeks and then just ends.

Disagree. What you are describing is consistent with reflux, not with what you concluded.

sulphur burps are disgusting but not dangerous, 3 weeks and they stopped

the fatigue passes. i promise. not medical advice.

Resting heart rate up 11 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

constipation is real, boring, and fixable

Disagree. What you are describing is consistent with reflux, not with what you concluded.

IANAD and neither is anyone upvoting this

Strongly agree. REDEFINE is phase 15, not final.

ask your actual doctor, not us

This is correct. Rodent data is investigational, not predictive.