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EL

u/elodie_grimaldi

Contributes reviews on supplier material. Based in Tours.

member · joined 16 Jul 2025

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Comments — page 2 of 5

comment on genuine question about incretin that I am slightly embarrassed to ask in c/glp1science · 32 points · 2 months ago

the 24-day half-life means week 24 is still ramp-up pharmacokinetically

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comment on [Meta] the retatrutide rule is doing its job and people should stop complaining in c/retatrutide · 2 points · 2 months ago

triple agonism is glucagon, do not generalise

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comment on tried concentration for 23 weeks. here is what happened. in c/reconstitution · 388 points · 2 months ago

i am begging people to write down the concentration

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comment on help me understand glucagon, I have read the wiki twice in c/retatrutide · 50 points · 3 months ago

Did you actually measure heart rate or is that a feeling?

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comment on what would you tell week-1 you about LC-MS in c/hplc · 1 points · 3 months ago

instrument quality is less important than analyst consistency

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comment on what would you tell week-1 you about LC-MS in c/hplc · 40 points · 3 months ago

This is the correct method framing. Column and gradient are load-bearing fields.

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comment on help me understand chromatogram, I have read the wiki twice in c/hplc · 2 points · 3 months ago

area% and mass% are not the same and this whole post conflates them

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comment on am I the only one who found titration harder than the injections in c/semaglutide · 40 points · 4 months ago

titration speed is weekly dosing plus side effects, period

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comment on someone explain semaglutide to me like I have not read a paper in years in c/semaglutide · 1 points · 4 months ago

week 17 on the pen, 45kg down, this is the answer

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comment on reading purity threads from 2024 and half of it aged badly in c/hplc · 385 points · 5 months ago

Gradient goblin mode: changed the solvent composition 17 times, finally got good resolution on a integration peak.

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comment on tried Wegovy for 11 weeks. here is what happened. in c/semaglutide · 299 points · 5 months ago

That is net peptide content, not purity. Different number, different meaning.

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comment on [Results] 17 weeks, 10kg, and LC-MS was the hard part in c/hplc · 7 points · 5 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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comment on [Results] 17 weeks, 10kg, and LC-MS was the hard part in c/hplc · 264 points · 5 months ago

the gradient is doing the separation work, not the column alone

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comment on what would you tell week-1 you about titration in c/semaglutide · 15 points · 6 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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comment on what would you tell week-1 you about titration in c/semaglutide · 35 points · 6 months ago

week 82 on the pen, 35kg down, this is the answer

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comment on 4 months in and dead space is still the thing I get wrong in c/reconstitution · 43 points · 6 months ago

more water means more units for the same dose, which means finer resolution

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comment on reading retatrutide threads from 2024 and half of it aged badly in c/retatrutide · 78 points · 7 months ago

nobody should be giving this to anyone without extensive monitoring

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comment on [Discussion] can we stop arguing about bacteriostatic water until somebody posts a number in c/reconstitution · 150 points · 7 months ago

the concentration on the vial in marker is the most important step

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comment on the semaglutide question that gets asked weekly, answered properly in c/semaglutide · 124 points · 7 months ago

The confident tone is doing a lot of work that the evidence is not.

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comment on [Question] how do you actually verify dead space in c/reconstitution · 40 points · 7 months ago

Cosigning. The concentration on the vial in marker is load-bearing.

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