u/emeka_chowdhury

Strongly agree. Mass% and area% are answering different questions on the same document.

Yeah, the evidence standard works.

Yeah, baseline matters more than any later number.

Baseline TSH: 99.3. Week 83: 95.1. Same lab, fasted, same time of day. Trend matters.

post reference ranges with your numbers, units differ by country and lab

This is correct. ApoB is the better marker.

Yeah, the incretin mechanism is doing the work here.

the method line is doing real work, not just window dressing

This is correct. ApoB is the better marker.

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

glucagon-receptor contribution is pharmacology for dual and triple agonism

Not to be pedantic but state board and 503A are being used interchangeably and they are not interchangeable in real life.

the shortage list is temporary, it ends and compounding becomes illegal again

Mechanistically the bit that matters is fertility. It explains most of the early profile and a decent chunk of the outcome.

the cycle tracking data matters, keep it private

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

Which country? Half the answers in this thread only apply in France.

Not convinced. The evidence does not support that reading.