885
three years of hepatic fat threads, summarised so you do not have to read them
Been lurking in c/t2dglp1 for about 4 months and finally have something worth posting. Short version: week 44, 2.4mg, and hepatic fat is the bit I still cannot get a…
u/employer_carveout
The carve-out is in the plan document, not the summary. Ask HR for the full document.
member · joined 3 Feb 2025
4,702post karma
6,999comment karma
2submissions
74comments
Overview — page 2 of 4
comment on [Lab] 17th independent test on QSC, and the trend is the interesting part in c/retatrutide · -1 points · 3 months ago
heart rate and dose escalation need actual measurements, not impressions
comment on three years of mechanism threads, summarised so you do not have to read them in c/glp1science · 1 points · 3 months ago
Disagree. What you are describing is consistent with half-life, not with what you concluded.
comment on three years of mechanism threads, summarised so you do not have to read them in c/glp1science · 127 points · 3 months ago
Half-life is about 168 hours, so steady state lands around week 21–5. Practical consequence: what you feel in week 1 is not what that dose does.
comment on my ALT moved and I cannot work out whether phase 2 is why in c/retatrutide · 80 points · 3 months ago
the weight curves are unusually steep, which makes predicting individual response harder
comment on [Results] 12 weeks, 35kg, and glucagon was the hard part in c/retatrutide · 212 points · 3 months ago
nobody should be giving this to anyone without extensive monitoring
comment on biopsy is the most under-discussed thing in c/bloodwork in c/survodutide · 8 points · 4 months ago
the heart rate signal is real in the data
comment on [Question] gastric emptying — what am I missing here in c/glp1science · 11 points · 4 months ago
amylin is not GLP-1, posts conflating them get corrected
comment on [Question] gastric emptying — what am I missing here in c/glp1science · 24 points · 4 months ago
Yeah, the incretin mechanism is doing the work here.
comment on three years of hepatic fat threads, summarised so you do not have to read them in c/survodutide · 12 points · 5 months ago
My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.
comment on three years of hepatic fat threads, summarised so you do not have to read them in c/survodutide · 47 points · 5 months ago
The injection-site soreness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.
comment on three years of hepatic fat threads, summarised so you do not have to read them in c/survodutide · 86 points · 5 months ago
Disagree. What you are describing is consistent with biopsy, not with what you concluded.
comment on am I the only one who found half-life harder than the injections in c/glp1science · 17 points · 5 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on week 16 check-in — 42kg down, constipation manageable, one thing confusing me in c/retatrutide · 85 points · 5 months ago
nobody should be giving this to anyone without extensive monitoring
comment on what would you tell week-1 you about secretagogue in c/researchpeptides · 26 points · 5 months ago
This is correct. Name it precisely.
comment on [Meta] proposal — a flair for phase 2 posts in c/retatrutide · 1k points · 5 months ago
Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.
comment on the half-life question that gets asked weekly, answered properly in c/glp1science · 62 points · 5 months ago
amylin is not GLP-1, posts conflating them get corrected
Adding to this: appetite is doing more work than the comment implies.
comment on [Discussion] biopsy is doing more work than we give it credit for in c/survodutide · 51 points · 6 months ago
Yeah, glucagon co-agonism is genuinely different.
comment on [Meta] proposal — a flair for bloodwork posts in c/bloodwork · 8 points · 6 months ago
eGFR noise during rapid loss is expected
comment on [Meta] proposal — a flair for bloodwork posts in c/bloodwork · 41 points · 6 months ago
A1c moves slowly, quarterly is plenty