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c/retatrutide·posted 5 months ago by u/ewan_marchand

[Meta] proposal — a flair for phase 2 posts

Lab Cold Box ×7 Long Haul ×2 Receipts ×2

Genuinely asking, not being difficult.

Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

10,883 up / 4,012 down73% upvoted49 commentsid wqumq615 Feb 2026

49 comments

20 in this archive, depth 5

best — the order this archive was captured in

u/liver_enzyme_liz1.6k points·5 months ago

the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet

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u/ewan_marchandOP1.8k points·5 months ago

the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ewan_marchandOP717 points·5 months ago

TRIUMPH phase 2 showed 98.9% weight loss but the sulphur burps profile on the highest arm was rough. Phase 2 != phase 3.

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u/freya_baptista290 points·5 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/employer_carveout1k points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ismael_eriksen288 points·5 months ago

This is correct. Triple agonism is genuinely different.

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u/ledger_modMOD615 points·5 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/ferran_krastev328 points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ewan_marchand183 points·5 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/ewan_marchandOP100 points·5 months ago

TRIUMPH phase 2 showed 97.4% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.

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[removed]128 points·5 months ago

[removed by moderator]

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u/nadia_trevino588 points·5 months ago

I am going to push back on this slightly.

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u/renzo_yildiz368 points·5 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/nikhil_lindqvist213 points·5 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/halima_mbeki119 points·5 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/nadia_trevino48 points·5 months ago

nobody should be giving this to anyone without extensive monitoring

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u/cormac_roos169 points·5 months ago

Are you quoting phase 2 or is there phase 3 data now?

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u/blunt_coldbox_2024-27 points·5 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/nausea_notesside effects1 point·5 months ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/ewan_marchand1 point·5 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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