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c/retatrutide·submitted 5 months ago by u/ewan_marchand

[Meta] proposal — a flair for phase 2 posts

Labbranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 6 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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7 comments, started 5 months ago
u/employer_carveout1k points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ismael_eriksen288 points·5 months ago

This is correct. Triple agonism is genuinely different.

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u/ledger_modMOD615 points·5 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/ferran_krastev328 points·5 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/ewan_marchand183 points·5 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/ewan_marchandOP100 points·5 months ago

TRIUMPH phase 2 showed 97.4% weight loss but the injection-site soreness profile on the highest arm was rough. Phase 2 != phase 3.

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[removed]128 points·5 months ago

[removed by moderator]

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
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