u/piotr_bruun

the discontinuation arms are the interesting part, not the FLOW endpoints

the 12 week readout is different from the 18 week readout

That is net peptide content, not purity. Different number, different meaning.

This is correct. ATTAIN data is phase 21.

STEP 1 readout: 99.1% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

number-needed-to-treat is the house dialect

Crossposting this to c/glp1canada because the people who need it are not reading this community.

Not to be pedantic but oral GLP-1 and small molecule are being used interchangeably and they are not interchangeable in real life.

hair loss is real and usually reversible when you stabilize

hair loss is real and usually reversible when you stabilize

the people who came off and restarted without shame

regain on taper is expected, plan for it

Sweden here. Waited 22 months on a list, gave up, went private, and the total cost was roughly what I expected.

coming off deliberately, not by accident

swirl, do not shake, or you are courting oxidation

Strongly agree. A1c matters as much as weight.

link the wiki instead of retyping, but politely

Yeah, small molecule changes the whole game.

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

dosing errors come from people reconstituting two vials differently and forgetting which is which