SELECT — 9 things I got wrong before I got it right
STEP. That is the whole post, but I will justify it.
Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does.
I say this having got it wrong for 18 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Is that absolute or relative risk reduction?
number-needed-to-treat is the house dialect
Yeah, absolute numbers matter more than the press release.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Sceptical. If this were true we would see it reflected in the data and we do not.
Yeah, absolute numbers matter more than the press release.
Phase 2 or phase 3?
phase 2 is not phase 3, smaller n and shorter trial
phase 2 is not phase 3, smaller n and shorter trial
Disagree on that part. 97.4% and 98.4% on the same vial is normal.
dropout handling matters, especially on GI-heavy populations
Yeah, absolute numbers matter more than the press release.
Phase 2 or phase 3?
Flair changed to match the content. Read the sidebar before posting next time and we are square.
absolute risk reduction, not relative risk reduction, that is how you decide
STEP 1 readout: 99.1% mean weight loss, absolute numbers matter. Spread around that mean is enormous.
the 16 week readout is different from the 5 week readout
That is net peptide content, not purity. Different number, different meaning.
give the trial name, phase, n, and primary endpoint in the body
give the trial name, phase, n, and primary endpoint in the body
Yes, exactly this, and it is the bit that took me 6 weeks to accept.
the discontinuation arms are the interesting part, not the endpoint endpoints
the relative risk reduction in headlines is not the whole story
- 1Phase 2 or phase 3?9 comments in this branch · started by u/yara_mensah
- 2Dead space in the needle hub holds a small but non-trivial volume. On…8 comments in this branch · started by u/first_hundred