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c/trialwatch·submitted 1 year ago by u/piotr_bruun

SELECT — 9 things I got wrong before I got it right

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STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort STEP out first, and almost nobody does. I say this having got it wrong for 18 months. My…

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8 comments, started 1 year ago
u/first_hundred136 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/sofia_wikstrom75 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/line_demir63 points·1 year ago

Is that absolute or relative risk reduction?

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u/piotr_bruunOP39 points·1 year ago

number-needed-to-treat is the house dialect

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[deleted]18 points·1 year ago

[deleted]

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u/week_four_wall168 points·1 year ago·edited

Yeah, absolute numbers matter more than the press release.

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u/nayeli_fonseca200 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/cesar_ivaturi61 points·1 year ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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