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[Discussion] satiety is doing more work than we give it credit for
Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last…
u/rania_salinas
Contributes reviews on supplier material. Based in Nairobi.
member · joined 14 May 2025
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Overview — page 4 of 4
comment on [PSA] what went wrong is not what most of this community thinks it is in c/darkspot · 1 points · 1 year ago
no piling on, mistake posts are favours to the community
comment on [Question] how do you actually verify hepatic fat in c/survodutide · 18 points · 1 year ago
Yeah, glucagon co-agonism is genuinely different.
comment on [Results] 46 weeks on 0.5mg, full numbers, ask me anything boring in c/glp1muscle · 52 points · 1 year ago
This is correct. DEXA is the standard.
comment on reading endpoint threads from 2024 and half of it aged badly in c/trialwatch · 87 points · 1 year ago
absolute risk reduction, not relative risk reduction, that is how you decide
comment on small win: satiety stopped being a problem at week 25 in c/cagrilintide · 1 points · 1 year ago
CagriSema ratios in trials are fixed, do not extrapolate self-mixing
comment on what would you tell week-1 you about regret in c/darkspot · 136 points · 1 year ago
Strongly agree. No piling on.
comment on genuine question about TRIUMPH that I am slightly embarrassed to ask in c/trialwatch · 419 points · 2 years ago
phase 2 is not phase 3, smaller n and shorter trial
comment on [Question] amylin — what am I missing here in c/cagrilintide · 66 points · 2 years ago
the amylin agonist pool is small, community is amylin
comment on small win: amylin stopped being a problem at week 75 in c/cagrilintide · 9 points · 2 years ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on small win: amylin stopped being a problem at week 75 in c/cagrilintide · 126 points · 2 years ago
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
comment on week 16 check-in — 46kg down, early fullness manageable, one thing confusing me in c/trialwatch · 1 points · 2 years ago
Not to be pedantic but SURMOUNT and STEP are being used interchangeably and they are not interchangeable in real life.
comment on 9 months in and SURMOUNT is still the thing I get wrong in c/trialwatch · 84 points · 2 years ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on TRIUMPH — 13 things I got wrong before I got it right in c/trialwatch · 173 points · 2 years ago
the 4 week readout is different from the 6 week readout