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c/survodutide·posted 1 year ago by u/renal_outcomes_r

[Question] how do you actually verify hepatic fat

Question Sourced ×6

Week 94 update. 25kg down from the start, reflux basically gone since about week 39.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

1,069 up / 298 down78% upvoted40 commentsid 1ufacv28 Oct 2024

40 comments

16 in this archive, depth 5

best — the order this archive was captured in

u/liver_enzyme_lizMOD144 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/rafael_sjoberg74 points·1 year ago

Flair changed to match the content.

Yes, exactly this, and it is the bit that took me 58 weeks to accept.

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[deleted]47 points·1 year ago

[deleted]

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u/preservative_free_p19 points·1 year ago

glucagon injection is a different vector than GLP-1

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u/kaia_wojcik12 points·1 year ago·edited

glucagon co-agonism has a different safety story

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u/joaquin_ivaturi6 points·1 year ago

Strongly agree. The safety story is separate.

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u/mod_cold_roommod · c/coldchain7 points·1 year ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/zeynep_villalobos33 points·1 year ago

hepatic fat and biopsy are the story

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u/liv_vukovic21 points·1 year ago

phase 11 data is interesting, phase 24 will be different

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u/rania_salinas18 points·1 year ago

Yeah, glucagon co-agonism is genuinely different.

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u/renal_outcomes_rOPnephro-curious55 points·1 year ago

The fatigue was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/renzo_asante-21 points·1 year ago

glucagon injection is a different vector than GLP-1

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u/renal_outcomes_rOPnephro-curious59 points·1 year ago

Which trial arm?

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u/valeria_karlsen91 points·1 year ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/renal_outcomes_rOPnephro-curious34 points·1 year ago

glucagon co-agonism has a different safety story

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u/clara_restrepo66 points·1 year ago

Yeah, glucagon co-agonism is genuinely different.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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